Early Preterm Birth: 200 mg vs 1,000 mg DHA in Gene Variant Carriers
Gene Variant Predicts Which Pregnant Women Benefit From Higher-Dose DHA
On 1,000 mg of DHA a day, carriers of one gene version had fewer early preterm births; non-carriers more often went past 40 weeks.
- 761 women analyzed
- 1,000 vs 200 mg DHA
- Early preterm: 4.3% to 1.1%
The same 1,000 milligrams of DHA cut early preterm birth in women with one version of this gene and did little for women without it, whose pregnancies more often ran past 40 weeks. I'd like to see prenatal DHA doses matched to the woman's genes. Genetic testing for this variant isn't routine yet, so for now I'd focus on steady DHA from food, like wild salmon, sardines and pasture-raised eggs, and plan any higher-dose supplement with your prenatal provider.
Source: PLOS Medicine · Oct 8, 2026





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